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The GDC DNA-Seq analysis pipeline identifies somatic variants within whole exome sequencing (WXS) and whole genome sequencing (WGS) data. Somatic variants are identified by comparing allele frequencies in normal and tumor sample alignments, annotating each mutation, and aggregating mutations from multiple cases into one project file.
(Fig. 12.1). RNA polymerase catalyzes the formation of phosphodiester bonds be-tween ribonucleotides using DNA as a template. Unlike DNA polymerase, RNA poly-merase does not require a primer to begin synthesis of the RNA molecule (see Chapter 2 for details of DNA synthesis). Growth of the RNA chain, like the growth of a DNA
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• Pap test – Identifies dysplasia / pre-cancer / cancer – Higher specificity/lower sensitivity • HPV test – Identifies women at risk – High negative predictivevalue (CIN, cancer) – Higher reproducibility • Combined approach – Co-testing with cytology (≥30y) – ASCUS-triage: follow-up interval (≥21y) Ann Intern Med 132 (10 ...
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DNA and RNA differ in the following way(s): DNA has a phosphate and RNA does not. DNA and RNA have different 5 carbon sugars. DNA and RNA have different nucleotides. All of the above. A and C. B and C. The function of messenger RNA (mRNA) is: To bring a sequence of nucleotides from DNA to the ribosome. To bind RNA to the ribosome
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